Saks Fifth Avenue, originally A. Saks & Co., is an American luxury department store chain, with its origins in Andrew Saks‘ A. Saks & Co. store opened in Washington, D.C.‘s F Street shopping district in 1867. Saks’ flagship store is located on Fifth Avenue in Midtown Manhattan, New York City. The 1924 New York store on Fifth Avenue lent its street name to the chain which would be known by what was originally the moniker of its flagship store, Saks Fifth Avenue.